Research

Our research focuses on computational methods for the analysis of complex mechanical and physiological systems. We develop multiscale, multiphysics, and patient-specific models that combine fluid mechanics, solid mechanics, and transport phenomena with medical imaging, physiological data, and data-informed methods. These models enable quantitative investigation of blood flow, tissue deformation, perfusion, and transport in cardiovascular and cerebrovascular systems. Our work aims to improve mechanistic understanding and support research in clinical assessment, treatment planning, and medical device design.

Our research is organized into three areas: computational methods, cardiovascular biomechanics, and cerebrovascular and brain mechanics.

Computational Methods

We develop computational frameworks for the efficient and quantitative analysis of multiscale and multiphysics systems, with particular emphasis on patient-specific applications.

A branching vascular network inside a three-dimensional tissue block — the large vessels drawn explicitly as a one-dimensional network, the small ones absorbed into the continuum, with the exchanges between them marked

Multiscale and Multiphysics Modeling

We couple models of different spatial dimensions and physical processes to analyze interactions among fluid flow, tissue deformation, and heat or mass transport.

One high-fidelity solution opening out into thousands of fast ones — a 3D coronary pressure field, the same vessel as a centerline model, and a spread of resulting FFR values

Efficient Computational Modeling and Uncertainty Quantification

We develop reduced-order and multi-fidelity methods to reduce computational cost and apply sensitivity analysis and uncertainty quantification to assess the effects of model parameters and physiological variability.

Cardiovascular Biomechanics

We develop computational models of cardiovascular flow and tissue mechanics to quantify the effects of vascular anatomy, physiological conditions, and mechanical loading on hemodynamic and biomechanical responses.

Patient-specific coronary simulation — anatomy with computed pressure field

Coronary Hemodynamics and Ischemic Heart Disease

We model pulsatile coronary flow, stenotic lesions, and collateral circulation to investigate pressure loss, myocardial perfusion, and functional indices such as fractional flow reserve.

One aneurysm, two fields — the flow inside the sac on one half, wall and thrombus loading on the other

Abdominal Aortic Aneurysm Hemodynamics and Mechanics

We combine hemodynamic and structural analyses to evaluate how vascular geometry, blood pressure, wall properties, and intraluminal thrombus affect mechanical indicators associated with aneurysm rupture.

A translucent lower limb with its venous network, the chamber pressure rising, tissue and lumen deforming, and flow rising again on release

Venous Hemodynamics and Intermittent Pneumatic Compression

We use coupled blood-flow and tissue-mechanics models to examine the effects of external pressure, tissue properties, and device parameters on lower-limb venous hemodynamics.

Cerebrovascular and Brain Mechanics

We develop computational models of cerebral hemodynamics and brain mechanics to investigate how vascular anatomy, physiological regulation, and external conditions affect cerebral perfusion and intracranial fluid behavior.

A brain with its arteries and tissue perfusion field, systemic pressure changing, arteriolar diameter answering, and perfusion returning to its regulated range

Cerebral Perfusion and Autoregulation

We model coupled arterial, microvascular, and venous systems to quantify the effects of autoregulation, anatomical variation, blood pressure, and posture on cerebral perfusion.

The Circle of Willis opening out along the major arteries into synthetic arteriolar trees, a stenosis on one artery, the territory behind it losing perfusion, and the collateral pathways that carry flow back to it

Cerebrovascular Networks and Collateral Circulation

We construct multiscale vascular networks and represent collateral circulation and arteriolar vasodilation to investigate tissue perfusion under ischemic conditions.

Project	Agency	Role
Cardiovascular and cerebrovascular M3DT based on patient-specific diagnostic technology	Ministry of Food and Drug Safety · KHIDI	Lead
Multiscale brain mechanics model for digital-twin-based brain monitoring	Samsung Research Funding & Incubation Center	Lead
Research center for a precision medicine platform based on smart hemodynamic indices	National Research Foundation of Korea	Joint
CNS-focused fluid-shift driven diseases: diagnosis and treatment	Ministry of Health and Welfare	Joint
Sustainable nuclear energy using spent-fuel chlorination and molten-salt fast reactors	KAIST	Joint